一、教育与工作经历
教育经历
w 博士 肿瘤学, 2016.9- 2019.6
南京医科大学
w 硕士 肿瘤学, 2006.9-2009.6
中南大学湘雅医学院
w 本科 临床医学, 2001.9-2006.6
中南大学湘雅医学院
工作经历
南京医科大学附属肿瘤医院
w 主任医师 放疗科 2023.12 至今
w 副主任医师 放疗科 2019.12 - 2023.12
w 主治医师 放疗科 2014.12 – 2019.11
w 住院医师 放疗科 2009.09 – 2014.11
二、主持科研项目(课题)情况
① 主持省部级课题:m7G修饰酶WDR4在鼻咽癌发生发展中的作用及机制研究。江苏省第六期“333工程”优秀青年人才项目(江苏省委组织部),2023.1-2025.12;在研。
② 主持国家级课题:外泌体传递EB病毒编码的miR-BART21-5P在促鼻咽癌转移中的机制。国家自然科学基金项目(82003232),2021.1-2023.12,已结题。
③ 主持市厅级课题:血浆外泌体膜蛋白SIGLEC5作为鼻咽癌早期诊断生物标志物的研究。南京市博士后课题优秀项目(南京市人社局),2024.1-2025.12;在研。
④ 主持市厅级课题:特异性外泌体膜蛋白 SIGLEC6 作为鼻咽癌早期诊断生物标志物及发病机制研究。江苏省卫健委预防医学面上项目(Ym2023109),2024.1-2026.12;在研。
⑤ 主持市厅级课题:外泌体中microRNA作为鼻咽癌血清新型生物标志物的研究。江苏省卫健委青年课题 (No. Q201601), 2017-2019;已结题。
⑥ 主持院所课题:鼻咽癌精确调强放疗后脑损伤的影像组学研究。 江苏省肿瘤医院临床科技攀登计划-“求真”临床研究专项(ZL202207),2023-2025;在研。
⑦ 主持院所课题:鼻咽癌患者血清中DNA甲基化的研究。江苏省肿瘤医院青年创新研究项目(No. ZQ201304), 2014-2016;已结题
三、社会任职
南京医科大学第四临床医学院 学科建设与研究生管理办公室主任(兼任)
中国研究型医院学会放射肿瘤学专业委员会委员
中国肿瘤放射治疗联盟放射免疫青年委员会委员
北京肿瘤防治研究会消化肿瘤分委会常务委员
江苏省抗癌协会鼻咽癌专业委员会委员及秘书
江苏省医师协会放射肿瘤治疗医师分会委员
江苏省抗癌协会肿瘤早筛及流行病学专委会委员
《肿瘤药学》编委; Oral Oncology、Journal of Cancer、Physical and
Engineering Sciences in Medicine、东南大学学报(医学版)、《现代
医学》、《广东医药》等专业杂志审稿专家
四、代表性研究成果和学术奖励情况
发表论著:
1、Binbin Chen, Ying Huang, Shuiqing He, Peng Yu, Lirong Wu*(吴俚蓉,通讯作者), Hao Peng*. N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis. Cell Chemical Biology 2023 30, 144–158. (Cell旗下重点子刊,生物学1区,SCI 9.04)
2、Binbin Chen, Wei Jiang, Ying Huang, Jian Zhang, Peng Yu, Lirong Wu (吴俚蓉,通讯作者), Hao Peng. N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma. Oncogene. 2022; Feb 26, 2022 . (Nature杂志旗下重点子刊,医学1区,SCI 10)
3、Xu T, Wu L (吴俚蓉,并列第一作者), Gandhi S, Jing W, Nguyen QN, Chen A, Chang JY, Nurieva R, Sheshadri A, Altan M, Lee PP, Lin SH, Liao Z. Treatment Related Pulmonary Adverse Events Induced by Chemoradiation and Durvalumab Affect Survival in Locally Advanced Non-Small Cell Lung Cancer. Radiotherapy Oncology. 2022 Oct 6:S0167-8140 (欧洲放射肿瘤学会会刊,放射肿瘤学顶刊,医学1区,SCI 8.4)
4、Lirong Wu(吴俚蓉,第一作者),Xiuming Zhang, Xiaodong Xie, Yue Lu, Jianfeng Wu, Xia He*. Validation of the 8th edition of AJCC/UICC staging system for nasopharyngeal carcinoma: Results from a non-endemic cohort with 10-year follow-up. Oral Oncology. 2019; 98: 141-146. (头颈部医学重点期刊,医学2区 SCI 5.3)
5、Lirong Wu(吴俚蓉,第一作者),Liu YT,Jiang N,Fan YX, Wen J, Huang SF, Guo WJ, Bian XH, Wang FJ, Li F, Song D, Wu JF, Jiang XS, Liu JY, He X. Ten-year Survival Outcomes for Patients with Nasopharyngeal Carcinoma Receiving Intensity Modulated Radiotherapy: An Analysis of 614 Patients from a Single Center. Oral Oncology. 2017; 69, 26–32. (头颈部医学重点期刊,医学2区 SCI 5.3)
6、Alvan Amos,Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He*, Yong Xu* and Lirong Wu* (吴俚蓉,通讯作者). Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition. BMC Cancer 2023 23:117. (英国BMC期刊,医学2区,SCI 4.3)
7、Jiawei Zhou, Li Wang, Ting Qiu, Han Gao , Lijun Wang, Shengfu Huang, Xia He, and Lirong Wu* (吴俚蓉,通讯作者). Long-term follow-up of protective effects on salivary and swallowing structures and improvement of late xerostomia and dysphagia by level IIb optimisation in clinical target volume of nasopharyngeal carcinoma. BMC Cancer, 2024 24:648. (英国BMC期刊,医学2区,SCI 4.3)
8、 Lirong Wu (吴俚蓉,第一作者), Xinxin Zhao, Suqing Tian, Kaixian Zhang, Chuang He, Yong Feng, Jiawei Zhou, Wenjie Guo, Zhe Ji, Xia He, Guanglie Chen and Junjie Wang. Efcacy and toxicity of Iodine-125 seed implantation for lymph node
recurrence secondary to esophageal cancer after radiotherapy: a multicenter retrospective study. Radiation Oncology. 2023 18:18. (美国放射肿瘤学专业期刊,医学2区,SCI 3.6分)
9、 Li Wang, Ting Qiu, Jiawei Zhou, Yinsu Zhu, Baozhou Sun, Guanyu Yang, Shengfu Huang, Lirong Wu* (吴俚蓉,通讯作者), Xia He*. A pretreatment multiparametric MRI-based radiomics-clinical machine learning model for predicting radiation-induced temporal lobe injury in patients with nasopharyngeal carcinoma. Head Neck, 2024,1-13. (美国头颈肿瘤专业期刊,医学3区,SCI 3.2分)
10、Lirong Wu(吴俚蓉,第一作者), Jun Zhu, Nils-Petter Rudqvist, James Welsh, Percy Lee, Zhongxing Liao, Ting Xu, Ming Jiang, Xiangzhi Zhu, Xuan Pan, Pansong Li, Zhipeng Zhou, Xia He, Rong Yin, Jifeng Feng. T-Cell Receptor Profiling and Prognosis After Stereotactic Body Radiation Therapy for Stage I Non-Small-Cell Lung Cancer. Frontiers in immunology. 2021, Oct 18;12:719285. (国际免疫学会联合会的官方期刊,医学1区,SCI 8.8)
国际会议摘要(壁报展示)
1 Lirong Wu, Xiangzhi Zhu, Zhongxing Liao, Ting Xu, Percy Lee, Nils Petter Rudqvist, James Welsh, Xuefeng Xia, Rong Yin, Jun Zhu, Xia He. TCR profiling to assess the efficacy/prognosis of Stereotactic Body Radiation Therapy in Stage I Non-Small-Cell Lung Cancer. American Society for Radiation Oncology (ASTRO) 2020 Congress. Miami, United States. (Publication Number: 2243).
2 Li-Rong Wu, Zhang, Xiuming; Xie, Xiao-Dong; Lu, Yue; Wu, Jian-Feng; He Xia. Validation of the 8th edition of AJCC/UICC staging system for nasopharyngeal carcinoma: Results from a non-endemic cohort with 10-year follow-up. European Society for Medical Oncology (ESMO) Asia Congress 2019. Singapore. 22-24 November, 2019 (Publication Number: 294P).
3 Li-Rong Wu, Xia He, Ye Shen. Genome-Wide Study of Salivary microRNAs As Potential Noninvasive Biomarkers for Detection of Nasopharyngeal Carcinoma. American Society for Radiation Oncology (ASTRO) 2019 Congress. Chicago, United States. 15-18 September, 2018 (Publication Number: 3555).
4 Li-Rong Wu, Huan-feng Zhu, Jianhua Xu, Xiu-hua Bian, Jian-feng Wu, Dan Song, Xue-song Jiang, Feng Li, Fei-jiang Wang, Sheng-fu Huang, Wen-jie Guo, Xia He. Effectiveness and toxicities of cetuximab in combination with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: A propensity score-matched analysis. European Societyfor Medical Oncology (ESMO) 2017 Congress. Annals of Oncology. Madrid, Spain 8-12 September, 2017 (Publication Number: 1072P).
5、Li Wang, Jiawei Zhou, Ting Qiu, Yinsu Zhu, Baozhou Sun, Guanyu Yang, Shengfu Huang, Xia He, Li-Rong Wu(吴俚蓉,通讯作者).Deep Transfer Learning and Dosiomics for Predicting RadiationInduced Temporal Lobe Injury in Nasopharyngeal Carcinoma
(ASTRO) 2024 Congress. Washington DC, United States. 29 September, 2024 (Publication Number: 62672). 美国放射肿瘤年会
6、Junyi Liu, L. Wang, J. Zhou1, T. Qiu1, Y. Zhu, B. Sun, G. Yang, S. Huang, X. He, and Li-Rong Wu(吴俚蓉,通讯作者). Compare the Predictive Performance of Deep Learning and Radiomics Models for Predicting Radiation-Induced Temporal Lobe Injury in Nasopharyngeal Carcinoma. (ASTRO) 2024 Congress. Washington DC, UnitedStates 29 September, 2024 (Publication Number: 64618). 美国放射肿瘤年会
7、Li Wang , Jiawei Zhou , Ting Qiu, Yinsu Zhu, Baozhou Sun, Guanyu Yang , Shengfu Huang, Li-Rong Wu(吴俚蓉,通讯作者), Xia He. A MRI-based radiomics-clinical machine learning model for predicting radiationinduced temporal lobe injury. Helsinki,Finland,29 June,2024 欧洲神经病学年会
获得奖项:
2023年 江苏省医学会 江苏医学科技奖 一等奖
2023年 江苏省抗癌协会科学技术奖 一等奖
2019年 江苏省新技术引进奖一等奖
2019年 获得欧洲肿瘤学会 ESMO Merit Award奖
编译书籍:
参与编写人卫版教材《肿瘤放射治疗学》,参与编译《血液系统恶性肿瘤放射治疗》、《亨迪放射治疗物理学》(第4版)。