北京大学医学博士

美国Cedars-Sinai(西达赛奈)医疗中心F.Widjaja基金会炎症性肠病和免疫生物学研究所博士后

研究方向：肠道微生态在炎症性肠病发生发展中作用机制的研究

主持国家自然科学基金、江苏省自然科学基金各一项

吴阶平医学基金会炎症性肠病联盟青年委员；《实用临床医药杂志》特约审稿专家

PEER-REVIEWED PUBLICATIONS:

1.       Xiaqiong Mao ,Jingjing Ma ,Chunhua Jiao , Nana Tang ,Xiao jingZhao ,Di Wang,Yue Zhang,Ziping Ye，Chenjing Xu,Jingyue Jiang,Shasha Wu,Xiufang Cui, Hongjie Zhang，and Xinyun Qiu. Faecalibacterium prausnitzii attenuates DSS-induced colitis by inhibiting the colonization and pathogenicity of Candida albicans. Molecular Nutrition & Food Research 2021; DOI: 10.1002/mnfr.202100433.R2

2.      Qiu X, Zhao X, Cui X, Mao X, Tang N, Jiao C, et al. Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn's disease. Therap Adv Gastroenterol 2020; 13:1756284820971202.

3.      Mao X, Qiu X (co-first author), Jiao C, Lu M, Zhao X, Li X, et al. Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens human intestinal barrier activity in Caco-2 cell monolayer model. Cytokine 2020; 126:154882.

4.      Qiu XY, Mao XQ, Zhang HJ. F. PRAUSNITZII PROTECT THE MICE FROM DEXTRAN-SULFATE SODIUM (DSS)-INDUCED COLITIS BY PROMOTING THE SECRETION OF GUT ANTI-MICROBIAL PEPTIDES AND INHIBITING THE REPRODUCTION, COLONIZATION AND PATHOGENICITY OF CANDIDA ALBICANS. Gastroenterology 2020; 158:S85-S.

5.      Zhao XJ, Li JJ, Ma JJ, Jiao CH, Qiu XY, Cui XF, et al. MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease. Inflammation 2020; 43:1862-75.

6.      Qiu XY, Lu MJ, Zhang HJ. Editorial: weighing the global risk of cancer with thiopurines in inflammatory bowel disease-Authors' reply. Alimentary Pharmacology & Therapeutics 2018; 47:690-1.

7.      Lu MJ, Qiu XY (co-first author), Mao XQ, Li XT, Zhang HJ. Systematic review with meta-analysis: thiopurines decrease the risk of colorectal neoplasia in patients with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 2018; 47:318-31.

8.      Qiu XY, Ma JJ, Wang K, Zhang HJ. Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis. Oncotarget 2017; 8:1031-45.

9.      Qiu XY, Ma JJ, Jiao CH, Mao XQ, Zhao XJ, Lu MJ, et al. Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis. Oncotarget 2017; 8:107577-88.

10.    Zhang F, Jiang WW, Li X, Qiu XY, Wu Z, Chi YJ, et al. Role of intrahepatic B cells in non-alcoholic fatty liver disease by secreting pro-inflammatory cytokines and regulating intrahepatic T cells. J Dig Dis 2016; 17:464-74.

11.    Qiu XY, Li X, Wu Z, Zhang F, Wang N, Wu N, et al. Fungal-bacterial interactions in mice with dextran sulfate sodium (DSS)-induced acute and chronic colitis. Rsc Advances 2016; 6:65995-6006.

12.    Zhang F, Jiang WW, Wu Z, Li X, Qiu XY, Liu YL. The role of B lymphocytes in the pathogenesis of non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology 2015; 30:328-.

13.    Qiu XY, Zhang F, Yang X, Wu N, Jiang WW, Li X, et al. Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis. Scientific Reports 2015; 5:1-12.

14.    Jiang WW, Wu N, Wang XM, Chi YJ, Zhang YY, Qiu XY, et al. Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease. Scientific Reports 2015; 5.

15.    Zhang MM, Qiu XY, Zhang H, Yang XT, Hong N, Yang YH, et al. Faecalibacterium prausnitzii Inhibits Interleukin-17 to Ameliorate Colorectal Colitis in Rats. Plos One 2014; 9:10.1371/journal.pone.0109146.

16.    Qiu XY, Zhang MM, Yang XT, Hong N, Yu CG. Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis. Journal of Crohns & Colitis 2013; 7:E558-E68.

中文文章

1）邱新运,刘玉兰. 真菌与炎症性肠病关系的研究进展. 中华消化杂志.2014,34(4):280-282

2）邱新运,刘玉兰.粪菌移植在疾病治疗中的应用进展. 中华内科杂志. 2014, 53(11):913-915.

3）邱新运,刘玉兰.肠道微生态重建在炎症性肠病治疗中的意义. 胃肠病学和肝病学杂志. 2015, 24(4):378-380.   

4）邱新运，洪娜，张明明，杨晓彤，于成功.Faecalibacterium prausnitzii对人外周血单核细胞IL-10、IL-12分泌以及CD25+Foxp3+Treg细胞分化的影响.胃肠病学.2012, 17(5): 283-287.

5）邱新运，于成功. Treg/Th17细胞分化失衡与炎症性肠病.胃肠病学2011,16(8):499-502.

6）洪娜,邱新运,张明明,杨晓彤,于成功. 普拉梭菌对实验性大鼠结肠炎防治的初步研究.中华消化杂志.2012,32(7):459-465

7）解玲玲，武娜，朱元民，邱新运，陈国栋，张黎明，刘玉兰. 结直肠腺瘤患者肠黏膜产肠毒素脆弱拟杆菌和表达pks基因的大肠埃希菌的分布.中华医学杂志. 2016,96(12):954-959.

3.参编书籍

(1) 武娜，蒋伟伟，邱新运，朱元明，刘玉兰，肠道生理和免疫学功能：肠黏膜屏障 ——生物屏障，整合肝肠病学——肝肠对话, 卢冬娅 陶峰, 人民卫生出版社, pp 81-105, 中国, 2014/5/1

RESEARCH PROJECT:

2017.1-2019.12   Faecalibacterium prausnitzii attenuates intestinal inflammation through inhibiting the colonization of Candida albicans in the gut of murine chronic IBD models. (F.prausnitzii抑制白色念珠菌在慢性IBD小鼠肠道中定植的机制及对肠炎的影响) National Natural Science Foundation of China (grant number: 81470827)

2016.07-2019.06 肠道共生菌F.prausnitzii对白色念珠菌的抑制作用机制及对IBD发生的影响  （江苏省自然科学基金青年项目 项目批准号：BK20161065）